Semaglutide and Tirzepatide: What to Know About These Weight Loss Injections

As many as 6% of Americans report having used the latest weight-loss injections – semaglutide and tirzepatide – to shrink their size. These medications, sold under the brand names Wegovy®, Mounjaro®, and Ozempic®, have definitely gained attention as promising tools in the battle against obesity. 

At Physicians Weight Loss Center Highlands Ranch, we provide these medications to qualifying patients. But, because they are relatively new to the weight-loss treatment scene, many questions exist about how they work and potential side effects.

Let’s answer important questions about semaglutide and tirzepatide, including what they are, how they work, and what you should consider before using them. 

Understanding semaglutide and tirzepatide

Both semaglutide and tirzepatide belong to a class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists, designed initially to help manage Type 2 diabetes. 

Physicians and researchers observed a significant impact on weight loss in people who took them to manage blood sugar. As a result, the companies have repurposed these medications for obesity management. 

Here are details about each one: 

Semaglutide

Known as Ozempic to treat diabetes, semaglutide is approved for weight loss under Wegovy. This medication mimics a naturally occurring hormone (GLP-1) that targets brain areas responsible for appetite and food intake. By enhancing feelings of fullness, it helps reduce caloric intake.

Tirzepatide

Tirzepatide is relatively new and works on two hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide). This dual action gives it a unique edge, as GIP reduces appetite and boosts the body's fat-burning ability.

How these medications work for weight loss

Both semaglutide and tirzepatide work by regulating hunger signals in the brain, curbing appetite, and enhancing satiety. 

These drugs slow gastric emptying – the rate at which food leaves your stomach – making you feel full longer. They also reduce your appetite by acting on the brain's appetite centers. You experience fewer cravings and the desire to overeat.

Although primarily known for their role in diabetes management, these medications help stabilize blood sugar levels, which can reduce spikes and crashes that often lead to overeating.

What to expect with semaglutide and tirzepatide

Clinical trials have shown impressive results with both medications. When combined with a healthy diet and lifestyle changes, patients taking Semaglutide for weight loss can expect an average loss of 15-20% of their body weight over the course of a year.

Studies on tirzepatide show even more promising outcomes, with patients potentially losing more weight than they do with semaglutide. However, this medication is newer to the weight loss market, and researchers are still collecting long-term data.

Side effects and considerations

Like all medications, semaglutide and tirzepatide come with potential side effects, most of which are related to the digestive system. These may include:

• Nausea
• Vomiting
• Diarrhea
• Constipation

Most side effects subside as your body adjusts to the medication. However, we thoroughly review your medical history before prescribing them. Patients with a history of pancreatitis, gallbladder issues, or certain types of thyroid cancer may not be eligible.

Candidates for semaglutide and tirzepatide

Weight loss medications like semaglutide and tirzepatide are typically prescribed to individuals with a BMI of 30 or higher or those with a BMI of 27 or higher who have weight-related health conditions, such as high blood pressure or type 2 diabetes. 

Semaglutide and tirzepatide offer exciting new options for those struggling with weight loss, especially when traditional methods have not been successful. We impress upon our patients that these medications are not magic, however. They should be used with lifestyle changes, including a balanced diet and regular physical activity.

If you're considering injectable weight loss medications or want to explore other options, contact us today to schedule your consultation to start working toward a healthier you.